Prep Question for project simulair to Edublogs

Hi there,

I'm about to setup a project that is similar to Edublogs. I already have the custom VPS setup and getting ready to install WPMU and Multi-DB. But before I do that, I was wondering if you guys have some tips to make sure this is done right.

Also I need to put up a job here to get the Multi-DB installed, but was wondering if it would be easier and smarter to wait with, me installing the WP Multisite (subdomain network) and have it done in one go. As I have seen what is needed to be done for the Multi DB.

Plus, what would be a smart move to make sure I can offer SSL to Mapped domains in the future.

Looking forward to hear from you.