Running multiple Mu sites and single sites off of one MU install?

Do you guys know if it is possible to run multiple domain mapped single blog sites + multiple (or even one) MU style w/ buddypress sites all off of one install of WPMU?

The reason I ask in I am thinking of consolidating all of my wordpress sites into on install of WPMU with the domain mapping plugin. And I have 2 (one buddypress one not) installs of WPMU that I would like to include.

Thanks