Safe_Mode - On or Off?

Hi,

Recently I've got a couple of clients who are using plugins that requires Safe_Mode to be Off on the server.

But my hosting's Safe_Mode is defaulted to On. The provider insisted on leaving Safe_Mode at On on concern of shared server security issue.

My question is, is it normal to switch Safe_Mode to Off? Or rather, is the Safe_Mode of most hosting out there turned On or Off?

Also, any of the plugin in WPMUDev requires Safe_Mode to be Off?

Best Regards,
William