Setting up MultiSite on an addon domain, not primary domain


Will this be problematic? I wish to set up a new group of sites as multi, this will be my first attempt at doing this, so please be gentle on me! I have hosting with a dedicated IP and several domains that are running as subs and of course a primary domain, all running wordpress single. None of these will be a part of my network. I wish to setup a new multisite installation and am wondering if I will need to change my current primary to an add on and use the domain for the multisite main site, as primary?