Setting Up New WPMU on new hosting

Hi Support,

I just signed up for new hosting and have become a yearly subscription member of you guys. Before I set up my server with WordPress, I need to know which is the best way to set this up for the best compatability of your products & services.

I have no clue when it comes to setting up via subdirectories or subdomains. What do you recommend I do?

I'm planning on adding your "Pro Sites", "Domain Mapping", etc.

Let me know what you think is best so I can set this up correctly from the beginning.

I appreciate you.

Mathew