should I use multisite for multiple urls

I have a number of people who want me to build sites for them. Thinking of setting up a multisite so that I can offer some of the wpmu multi-site options as well as hosting - but they sites will all have different urls- rather than be subdomains.

I know there are plugins that will facilitate multiple url's on a multisite install but I'm wondering if I am creating more complications than I need to.

Thoughts? Multi-site to accommodate multiple clients with separate url's or chuck it and just set up separate installs?