[Smush Pro] Best practices: Bulk Smush, CDN, or both?

The settings seem to suggest either Bulk Smush or CDN loading, not both. (On the CDN settings page, “Automatically compress and resize your images with bulk Smush, or upload them to the WPMU DEV’s blazing-fast CDN…” ) Is it indeed one vs. the other, or is it OK to do Bulk Smush first, then enable CDN?