So I recently setup wp multisite 3.6, I am trying to figure

So I recently setup wp multisite 3.6, I am trying to figure out how to maximise the power of the platform.

I have mydomain.com setup to use
site1.mydomain.com and I was wondering if more.site1.mydomain.com is possible.

So for example I create a site for a client myclient.mydomain.com
and they wants to offer blogs to their clients blogs.myclient.mydomain.com
, How do I set this up?
Thanks!!