Spirit behaving strangely - media pane not loading


I've got a fresh installation of Upfront / Spirit but for some reason I can't get it to work. The menus are appearing strangely and the media window doesn't load. Instead the page blurs but the panel never opens. I've attached screenshots.

I found another thread that had an apache setting we needed to try and the ?dev=true&editmode=true in the URL option. The apache setting didn't work - and then using that extra parameter did make upfront load properly - but my changes didn't save.

I'd appreciate any assistance you can provide.

I've already turned support access on.