My VPS webhost has this recommendation:
You want to consider switching from suPHP to DSO w/ Mod RUID2 with a php cache - xcache or Eaccelerator.
Many people have success implementing DSO w/mod_ruid2 & an accelerator. This is a much faster setup; however, mod_ruid2 is incompatible with certain modules.
Since I only use Wordpress, and 95% of my plugins and themes are from WPMUDEV, just want to ask if you guys are aware of any potential issues with this.