Two WP multisite installs on the same server


I was wondering if it's possible to have two WP multisite installations on the same server. I have a Hostgator reseller account.

I currently have MS for my network of my company's sites, but I want to create another MS environment and use domain mapping to create and manage my clients' sites.

Would this simply be a matter of creating another WP install in a separate folder on my server? Or is it more complicated than that?

Assuming this is is possible, what recommendations do you have for making this environment secure and simple to manage/maintain? How would the databases be managed/kept separate?

Any other recommendations would be tremendously appreciated!

Thanks in advance for your help!