Using the WHMCS plug-ins : Can I use one WHMCS install and run/access it from multiple WPMU install

I have not tried setting this up yet. I am just trying to get my head around how this works.
I have one license for WHMCS and am going to install it on the main site for my reseller account. I have multiple other WPMU networks set up on other domains. So the question is, do I install the WHMCS related plugins on each network... and will this work... with the WHMCS installed on a different domain?