Varnish cache multisite compatibility info

Hi all, i have been optimising the blogs with W3TC and its working 100% .
I went to GTmetrix and generated a report, in some blogs the page speed value was 92 and yslow with a score of 86, also i don't have minify options or CDN enabled yet :slight_smile:

Im thinking setting up the varnish cache for whm cpanel but i don't know about the compatibility with multisite networks using domain mapping and multi-domain plugins, does anyone know if Varnish cache is compatible with multisite networks?