Warning on Site Creation in Network Admin

I started getting the following on new site creation via the Add New Site in the Net Work Admin and I was hopping someone could point me in the right direction of what to look so not flying blind.

Warning: fopen(/home/MYPATH/public_html/wp-content/plugins/EMPTY) [function.fopen]: failed to open stream: No such file or directory in /home/MYPATH/public_html/wp-includes/functions.php on line 4452

Warning: fread(): supplied argument is not a valid stream resource in /home/MYPATH/public_html/wp-includes/functions.php on line 4455

Warning: fclose(): supplied argument is not a valid stream resource in /home/MYPATH/public_html/wp-includes/functions.php on line 4458

Warning: Cannot modify header information - headers already sent by (output started at /home/MYPATH/public_html/wp-includes/functions.php:4452) in /home/MYPATH/public_html/wp-includes/pluggable.php on line 866

Even with the errors the site gets created and emails sent out.

WordPress Version: 3.3.2