What is the best method to backup an entire multisite running multi db?

What is the best method to backup an entire multisite running multi db several times a day and automatically?

I would prefer more than 1 option just incase that backup corrupts. I have an entire server backup in place to restore the server but looking for some wordpress specific.

I know there is plenty out there but its finding ones that would work with multi db.

Would love to know how edu blogs do this.

Thanks