which cache plugin is best suited for MP and WPMU plugins

Hi,

As of using MP and multisite, i am using mainly all WPMU plugins etc, and trying to avoid the minimum 3rd party plugins , But the wp with ultimate branding and lots of others site is slow . So please suggest me which cache plugin is best suited for MP and WPMU plugins

and what modifications i have to do for this plugins to MP or any other plugin of yours.

same for SEO

Regards,
Ajay