WP 3.0: is enabling multisites right out of the box a good practice

Hello,

I've read in a few places that in prior versions of WP before 3.0, if you are using Buddy Press, it is just a good idea to have the WPMU installed and activated just in case you do decide to start more blogs. Right now, I have no plans to offer multiple blogs on my site, but I may want one or two separate blogs to run sections to look like my blog like for a voting/contest section, calendar section, etc. If I went ran my blog for a while having the multisites component inactive, then needed to activate it, can this cause headaches?

I heard this was a problem with WP 2.9 and prior, just wondering if this is still the case with the new WP 3.0.

Thanks