WP Smush Pro API Not Connected - Service Unavailable

Trying to activate WP Smush Pro and it does not appear to be working. Seeing a "API Not Connected" error at the top of the settings page along with "Service Unavailable" error at the bottom of the same page.

When trying to Smush an individual media file, receiving the following error "Oh Snap! Seems like Smush Pro server is not reachable, you can try back in some time."

We are using W3 Total Cache and a CDN service which may be causing things to not function appropriately. Looking for some guidance here?

The plugin is set-up per the instructions with WPMU Dev Network activated and attempted to Network Activate WP Smush Pro, along with trying individual site activation of WP Smush Pro with the same results. I look forward to your assistance.