WPMUDEV plugins with Nginx, Varnish, Memcached server


I am planning to deploy Nginx, Varnish, Memcached infront of Apache for my server at Digital Ocean. I have seen some old posts where WPMU with domain mapping was having some issues. I just wanted to check if those issues have now been all resolved and domain mapping is seamless. In my current server I have nginx and I am able to map new domains dring test. But with new server with varnish etc, i hope it will continue to be ok Kindly let me know if you have had issues recently and how did you overcome.